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Related Experiment Videos

Two-component arterial blood pressure conditional response in rat

D C Randall1, D R Brown, L V Brown

  • 1Dept. of Physiology and Biophysics, University of Kentucky College of Medicine, Lexington 40536-0084.

Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society
|July 1, 1993
PubMed
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This study quantifies arterial blood pressure changes in rats during aversive classical conditioning. High-resolution analysis revealed distinct blood pressure patterns differentiating conditioned stimuli, highlighting the paradigm's potential for future research.

Area of Science:

  • Neuroscience
  • Physiology
  • Behavioral Science

Background:

  • Classical conditioning is a fundamental learning process.
  • Quantifying physiological responses like blood pressure (BP) is crucial for understanding learning.
  • Previous methods lacked the resolution to capture detailed BP dynamics during conditioning.

Purpose of the Study:

  • To quantify arterial blood pressure (BP) patterns during a discriminative aversive classical conditioning paradigm in rats.
  • To utilize a novel high-resolution computer analysis for precise BP measurement.
  • To assess the ability of rats to discriminate between conditioned stimuli based on BP responses.

Main Methods:

  • Sprague-Dawley rats underwent classical conditioning with a tone (CS+) followed by tail shock, and a distinct tone (CS-) never paired with shock.

Related Experiment Videos

  • Arterial blood pressure was continuously monitored using a high-resolution computer analysis system.
  • Two conditioning protocols were used: short (6 sec) and long (15 sec) tones, with subsequent analysis of BP components (C1 and C2) and respiratory patterns.

    • Main Results:

    • A significant "first component" (C1) of BP increase was observed for both CS+ and CS-, with a statistically significant difference in magnitude between them.
    • With longer tones, a "second component" (C2) of BP increase was observed specifically during CS+ trials, indicating successful discrimination.
    • Respiration patterns shifted post-shock, showing apneic episodes linked to significant BP fluctuations.

    Conclusions:

    • The high-resolution analysis effectively quantified distinct arterial blood pressure responses during discriminative aversive classical conditioning in rats.
    • The observed two-component BP response and differential C2 for CS+ demonstrate the paradigm's efficacy in eliciting learned discrimination.
    • This rat conditioning model shows promise for future research, particularly for recording sympathetic nerve activity and utilizing genetic models of human diseases.