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Increased risk of aneuploidy in women having unsuccessful chorionic villus sampling procedures
A E Donnenfeld1, R J Librizzi, S Weiner
1Department of Obstetrics and Gynaecology, Pennsylvania Hospital, Philadelphia 19107.
Objective:
To determine the incidence of fetal aneuploidy in women who had unsuccessful chorionic villus sampling (CVS) procedures.
Design:
Retrospective study.
Setting:
Pennsylvania Hospital, Philadelphia, Pennsylvania, USA.
Subjects:
Two thousand six hundred and sixty-eight women who underwent chorionic villus sampling, in 78 (2.9%) of whom villi could not be obtained.
Interventions:
Sixty-nine of 78 (88%) women who had an unsuccessful CVS procedure underwent a subsequent amniocentesis later in the same pregnancy.
Main Outcome Measures:
The incidence of aneuploidy identified from amniotic fluid chromosome analysis in the 69 women who had an unsuccessful CVS procedure compared to the frequency of aneuploidy in women having a successful CVS procedure.
Results:
Of the 69 women who underwent a post-CVS amniocentesis because of failure to obtain chorionic villi, six aneuploid pregnancies were identified (8.7%). The frequency of aneuploidy in the 2590 successfully sampled CVS patients was 2.5%. This difference was statistically significant (P = 0.009) by Fisher's exact test (two-tailed).
Conclusions:
Women having an unsuccessful CVS procedure should be informed that they may be at increased risk for carrying an aneuploid fetus.