Modern treatment approaches for Hodgkin's disease

Recent studies are refining the treatment approaches of radiation therapy and combination chemotherapy in Hodgkin's disease. In early-stage disease, attempts are being made to lessen the toxicity of treatment while maintaining excellent results. Optimal results are achieved in advanced disease with combined radiation therapy and chemotherapy, most often with alternating or hybrid regimens. Several groups have attempted to define a poor-prognosis group of patients with advanced disease who might be candidates for more intensive treatment.