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Biodegradable poly(DL-lactic acid) formulations in a calcitonin delivery system
1Department of Material Development, Japan Atomic Energy Research Institute, Gunma.
Biomaterials
|August 1, 1993
Summary
Biodegradable poly(DL-lactic acids) were used to encapsulate a synthetic eel calcitonin analogue. Drug release varied by polymer molecular weight, with lower molecular weights showing rapid release and higher molecular weights providing sustained release over 24 days.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Pharmacology
Background:
- Synthetic analogues of eel calcitonin, such as [Asu1, 7]-ECT, are investigated for therapeutic applications.
- Biodegradable polymers like poly(DL-lactic acids) are crucial for controlled drug delivery systems.
Purpose of the Study:
- To incorporate [Asu1, 7]-ECT into poly(DL-lactic acids) with varying molecular weights (Mn = 1400-4400).
- To evaluate the in vitro drug release profiles from these polymer matrices.
Main Methods:
- Melt-pressing technique used for polymer-drug incorporation.
- In vitro drug release studies conducted over a 24-day period.
- Analysis of drug release kinetics based on polymer degradation patterns (parabolic and S-type).
Main Results:
- Poly(DL-lactic acid) with Mn = 1400 exhibited an initial burst release, completing drug release within 3 days.
- Poly(DL-lactic acid) with Mn = 4400 demonstrated an S-type degradation pattern, maintaining a sustained release of 14 ± 5 units/day for 24 days.
Conclusions:
- Polymer molecular weight significantly influences the drug release profile of [Asu1, 7]-ECT.
- Higher molecular weight poly(DL-lactic acids) offer potential for sustained delivery of synthetic eel calcitonin analogues.