Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacterium-induced autoimmune reactivity

C Hol1, P Bloembergen, H van Dijk

  • 1Department of Medical Microbiology, Public Health Laboratory, Leeuwarden, The Netherlands.

Autoimmunity
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variations in ageing and meristematic activity in relation to flower-bud and fruit excision in the Beta species complex.

The New phytologist·2021
Same author

Direct and indirect estimates of the selfing rate in small and large individuals of the bumblebee pollinated Cynoglossum officinale L (Boraginaceae).

Ecology letters·2021
Same author

The "1958 He<sup>4</sup> Scale of Temperatures": Part 2. Tables for the 1958 Temperature Scale.

Journal of research of the National Bureau of Standards. Section A, Physics and chemistry·2020
Same author

Spatial clustering and livestock exposure as risk factor for community-acquired Clostridium difficile infection.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018
Same author

Increasing self-directed training in neurorehabilitation patients through competition.

Progress in brain research·2016
Same author

Conflicts, security and marginalisation: institutional change of the pastoral commons in a 'glocal' world.

Revue scientifique et technique (International Office of Epizootics)·2016

Microbial factors, like Escherichia coli and Salmonella typhimurium, can induce autoimmune reactivity. Smooth bacteria strains are more potent in triggering autoimmune responses than rough strains, suggesting a role in autoimmune disease etiology.

Area of Science:

  • Immunology
  • Microbiology
  • Autoimmunity

Background:

  • Autoimmune reactivity arises from interactions between genetic predisposition and environmental triggers.
  • Microbial factors are increasingly recognized as potential environmental contributors to autoimmune diseases.

Purpose of the Study:

  • To investigate the role of microbial factors in inducing autoimmune reactivity.
  • To compare the autoimmune-inducing potential of different bacterial strains and their components.

Main Methods:

  • Experimental infection of mice with Escherichia coli and Salmonella typhimurium.
  • Measurement of splenic anti-erythrocyte antibodies and circulating immune complexes.
  • Correlation of findings with live bacteria and their corresponding endotoxins.

Related Experiment Videos

Main Results:

  • Experimental infections with E. coli and S. typhimurium induced significant autoimmune reactivity.
  • Smooth bacterial strains were approximately ten times more potent than rough mutant strains in inducing autoimmune responses.
  • A correlation was attempted between live bacteria and their endotoxins.

Conclusions:

  • Bacterium-derived factors play a role in the etiology and potentially the progression of autoimmune diseases.
  • The enhanced autoimmune reactivity induced by smooth bacteria is likely due to their longer survival in vivo.
  • These findings support the hypothesis that microbial exposures can trigger or exacerbate autoimmune conditions.