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Transient elevation in catalytic trkB mRNA during postnatal development of the rat brain
M M Dugich-Djordjevic1, F Ohsawa, F Hefti
1Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
Neuroreport
|September 1, 1993
Abstract:
Quantitative in situ hybridization analysis of catalytic (trkB TK+) and non-catalytic (trkB TK-) trkB mRNAs in the postnatal rat brain demonstrated regional differences in expression and revealed transient increases in trkB TK+ expression. Hybridization of trkB TK+ mRNA was observed in thalamic nuclei between P4 and P8, but not in the adult. In hippocampal structures, transient elevations of trkB TK+ mRNA were apparent between P13 and P17. In contrast, there was a gradual developmental increase in trkB TK- mRNA expression in the hippocampus.