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[Prognostic factors in typhoid perforation]

C Paredes1, J Cruz, J Díaz-Plasencia

  • 1Departamento de Cirugía del Hospital, Belén de Trujillo, Facultad de Medicina de la U.N.T.

Revista De Gastroenterologia Del Peru : Organo Oficial De La Sociedad De Gastroenterologia Del Peru
|January 1, 1993
PubMed
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This study on typhoid perforation surgery identified key predictors of poor outcomes. Factors like prolonged perforation, hematochezia, leukopenia, and multiple perforations significantly increase postoperative morbidity and mortality risks.

Area of Science:

  • Gastroenterology and Surgery
  • Infectious Diseases
  • Clinical Epidemiology

Context:

  • Typhoid perforation remains a significant surgical challenge, particularly in resource-limited settings.
  • This study examines surgical outcomes for typhoid perforation over a 23-year period.
  • Understanding predictive factors is crucial for improving patient management.

Purpose:

  • To identify factors associated with postoperative morbidity and mortality in patients undergoing surgery for typhoid perforation.
  • To conduct a univariate analysis of clinical and surgical parameters.
  • To inform surgical decision-making and patient care.

Summary:

  • A retrospective analysis of 112 patients undergoing surgery for typhoid perforation was performed.

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  • Key predictors of postoperative mortality included perforation duration over 48 hours, hematochezia, leukopenia, fecaloid peritoneal fluid, and three or more perforations.
  • Morbidity was significantly associated with perforations exceeding 48 hours.

    • Impact:

    • Identifies critical risk factors for typhoid perforation surgery, enabling better preoperative risk assessment.
    • Highlights the importance of timely surgical intervention to reduce perforation duration.
    • Provides evidence-based insights for surgeons to improve outcomes in typhoid perforation cases.