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CD8 and antigen-specific T cell adhesion cascades

A M O'Rourke1, B Ybarrondo, M F Mescher

  • 1Division of Membrane Biology, Medical Biology Institute, La Jolla, CA 92037.

Seminars in Immunology
|August 1, 1993
PubMed
Summary

T cell activation relies on the T cell receptor and accessory receptors like CD8, LFA-1, and VLA. These receptors work together in a cascade, not redundantly, to ensure full cellular response activation.

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Journal of immunology (Baltimore, Md. : 1950)·2001

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • T cell activation requires the T cell receptor (TCR) and accessory receptors.
  • Accessory receptors, including CD8, LFA-1, and VLA, are crucial for cytotoxic T lymphocyte function.

Purpose of the Study:

  • To investigate the role of accessory receptors in T cell activation.
  • To understand how accessory receptors mediate adhesion and co-stimulation upon TCR crosslinking.
  • To elucidate the coordinated function of accessory receptors in T cell activation cascades.

Main Methods:

  • Studies involved crosslinking of the T cell receptor.
  • Analysis of accessory receptor activation, adhesion, and co-stimulatory signaling.
  • Investigation of the sequential events in T cell activation.

Main Results:

  • Accessory receptors (CD8, LFA-1, VLA) are activated upon TCR crosslinking.
  • These receptors mediate adhesion and provide co-stimulatory signals.
  • Receptor interactions occur in a cascade, leading to full T cell activation.

Conclusions:

  • Accessory receptors are not redundant but participate in a critical cascade.
  • This cascade of adhesion and signaling events is essential for robust T cell responses.
  • Understanding these interactions is key to T cell-mediated immunity.

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