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Updated: Sep 2, 2026

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
Published on: September 25, 2016
[The imaging diagnosis of acute cerebral tuberculosis]
M Rütschle1, G Schroth, W Wichmann
1Neuroradiologische Abteilungen, Universitätsspitäler Zürich.
Abstract:
5 unusual cases of cerebral tuberculosis are reported. Three of the cases initially showed the typical history and aspect of herpes simplex encephalitis, and two of a cerebral tumour. Both CT and MRI, and also the clinical neurological symptoms, were confusing. Microbiological culture in three and histological preparation in two cases confirmed the diagnosis of cerebral tuberculosis. Three cases showed the development of tuberculomas under therapy. The study of the literature suggests that this is not rare, which is explained by pathogenetic reflexions concerning the allergic genesis of the tuberculomas.
Insights
Cerebral tuberculosis can mimic herpes simplex encephalitis or brain tumors, complicating diagnosis. Early recognition and treatment are crucial, as tuberculomas may develop even during therapy.
Area of Science:
- Neurology
- Infectious Diseases
- Radiology
Background:
- Cerebral tuberculosis presents diagnostic challenges, often mimicking other neurological conditions.
- Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) findings can be ambiguous.
Observation:
- Five unusual cases of cerebral tuberculosis are presented.
- Three cases initially resembled herpes simplex encephalitis.
- Two cases presented as cerebral tumors.
Findings:
- Diagnosis was confirmed via microbiological culture (3 cases) and histological examination (2 cases).
- Tuberculomas developed in three patients during treatment.
- Literature review suggests this presentation is not uncommon.
Implications:
- Highlights the need for considering cerebral tuberculosis in differential diagnoses of complex neurological presentations.
- Suggests allergic genesis may play a role in tuberculoma formation.
- Emphasizes the importance of advanced imaging and microbiological confirmation for accurate diagnosis.
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