Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-beta receptor family

¹Department of Pharmacology, Kawasaki Medical School, Kurashiki City, Japan.

DNA Sequence : the Journal of DNA Sequencing and Mapping

|January 1, 1993

Abstract:

We have isolated RPK-2 cDNA from chick embryo cDNA library that encodes a receptor protein kinase of the TGF-beta receptor subfamily. The deduced amino acid sequence reveals the presence of a hydrophobic transmembrane helix and a kinase domain distantly related to type II receptor for TGF-beta. The kinase domain sequence is most similar to RPK-1 identified recently in the chick embryo. Several cysteine residues are contained in the amino-terminal ectodomain, suggesting the protein as a receptor for a peptide growth factor of the TGF-beta family.

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Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-beta receptor family

Abstract:

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