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Variability in plasma lipoprotein profiles when comparing diltiazem and propranolol
D G Labreche1, G T Kondos, D W Bartels
1College of Pharmacy, University of Connecticut, Farmington.
The Annals of Pharmacotherapy
|September 1, 1993
Summary
Diltiazem and propranolol did not significantly alter plasma lipoproteins in hypertensive patients. Observed lipoprotein changes may reflect normal patient variability rather than drug effects.
Area of Science:
- Cardiovascular pharmacology
- Lipid metabolism
Background:
- Antihypertensive medications can influence lipid profiles.
- Understanding these effects is crucial for managing cardiovascular risk.
Purpose of the Study:
- To compare the effects of diltiazem and propranolol on plasma lipoproteins.
- To determine if observed lipoprotein changes are drug-induced or due to natural variation.
Main Methods:
- Double-blind, comparative trial with 21 hypertensive patients.
- Patients received either sustained-release diltiazem or propranolol after placebo run-in.
- Plasma lipoproteins (total cholesterol, HDL, LDL, VLDL) were measured.
Main Results:
- No significant changes in lipoprotein concentrations were observed with diltiazem or propranolol.
- Significant bidirectional variations in lipoproteins were noted during placebo, similar in magnitude to drug treatment periods.
- Intrapatient variability was a prominent factor.
Conclusions:
- Reported changes in plasma lipoproteins attributed to antihypertensive drugs may be influenced by normal intrapatient variability.
- This variability should be considered when interpreting lipid profile changes during treatment.