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Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography
1Department of Veterinary Pharmacology, University of Glasgow Veterinary School, UK.
Biomedical Chromatography : BMC
|July 1, 1993
Abstract:
A high performance liquid chromatographic method has been developed for the determination of rafoxanide and closantel in ovine plasma. Acetonitrile and chloroform were used for the extraction. The mean recoveries were 78.69% and 80.59% for rafoxanide and closantel, respectively. This method was applied to the characterization of rafoxanide plasma kinetics following oral administration of therapeutic doses to sheep.