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Serotypes of group B meningococci

D M Jones, B M Tobin

    Journal of Clinical Pathology
    |August 1, 1976
    PubMed
    Summary

    Serogroup B meningococci causing infections in the UK predominantly possess serotype 2 antigen. These specific strains were less common in asymptomatic carriers without meningococcal disease.

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    Area of Science:

    • Microbiology
    • Immunology
    • Epidemiology

    Background:

    • Neisseria meningitidis (meningococcus) is a significant bacterial pathogen.
    • Serogroup B meningococci are a major cause of bacterial meningitis and sepsis.
    • Understanding meningococcal serotypes is crucial for disease surveillance and control.

    Purpose of the Study:

    • To serologically characterize strains of group B meningococci.
    • To investigate the association between specific serotypes and clinical outcomes (sporadic vs. epidemic infections).
    • To compare serotypes found in patients with those found in asymptomatic carriers.

    Main Methods:

    • Serological typing technique was employed.
    • Meningococcal strains were isolated from various sources: clinical cases (sporadic and epidemic) and asymptomatic carriers.
    • Antigenic characterization of group B meningococcal strains.

    Main Results:

    • The majority of group B meningococcal strains from clinical infections in the United Kingdom exhibited serotype 2 antigen.
    • Serotype 2 strains were found to be relatively uncommon among carriers without a history of meningococcal disease.
    • This suggests a potential link between serotype 2 and invasive disease.

    Conclusions:

    • Serotype 2 antigen is a predominant characteristic of group B meningococci causing clinical infections in the UK.
    • The lower prevalence of serotype 2 in asymptomatic carriers suggests it may be more associated with disease-causing potential.
    • Further research into the virulence factors of serotype 2 strains is warranted.

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