Partial trisomy 1q, an uncommon chromosomal aberration in erythroleukemia
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Updated: Nov 8, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
E Baumgarten1, R D Wegner, R Fengler
1Universitätsklinik Rudolf Virchow, Charlottenburg, Kinderklinik Abt. Hämatologie/Onkologie, Berlin, Germany.
Abstract:
A 2 years 4 months old boy with erythroleukemia (FAB-M6) and Down's syndrome is described. Chromosome analysis of bone marrow leukemic blasts revealed apart from the trisomy 21 a partial trisomy of the long arm of chromosome 1:1q23-->1qter in all cells and trisomy 8 mosaicism. To the best of our knowledge this is the first time that a partial trisomy of chromosome 1 in association with erythroleukemia has been described. Previous reports of other hematologic malignancies with aberrations of chromosome 1 indicate that the breakpoint 1q23 is nonrandom and that trisomies of chromosome 1 plays a crucial role in the course of development of hematologic malignancies. This could probably also be true for erythroleukemias.
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