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Vitamin E in extrapyramidal disorders
L Bischot1, G Van den Brink, A J Porsius
1Department of Pharmacotherapy, Faculty of Pharmacy, Utrecht University, The Netherlands.
Pharmacy World & Science : PWS
|August 20, 1993
Summary
Vitamin E showed symptom improvement in tardive dyskinesia patients. However, large trials found no benefit for Parkinson's disease, suggesting it may not be an effective treatment for this neurodegenerative disorder.
Area of Science:
- Neurology
- Nutritional Neuroscience
Background:
- Extrapyramidal disorders, including tardive dyskinesia and Parkinson's disease, present complex neurological challenges.
- Understanding the pathogenesis of these conditions is crucial for developing effective treatments.
Purpose of the Study:
- To review the scientific literature on the efficacy of vitamin E in managing tardive dyskinesia and Parkinson's disease.
- To synthesize findings from clinical trials investigating vitamin E's therapeutic potential.
Main Methods:
- Review of existing clinical research, including double-blind, placebo-controlled trials.
- Analysis of studies examining vitamin E's effects on symptom presentation and disease progression.
Main Results:
- Four double-blind, placebo-controlled trials indicated symptom improvement in tardive dyskinesia with vitamin E (up to 1,600 IU/day).
- Preliminary Parkinson's disease research suggested vitamin E (2,000 IU/day) might not prevent disease onset but could potentially slow progression.
- A large double-blind, placebo-controlled trial found no beneficial effect of vitamin E in Parkinson's disease.
Conclusions:
- Vitamin E demonstrates potential therapeutic benefits for tardive dyskinesia symptoms.
- Current evidence does not support the use of vitamin E for Parkinson's disease treatment or prevention.