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Vitamin E in extrapyramidal disorders

L Bischot1, G Van den Brink, A J Porsius

  • 1Department of Pharmacotherapy, Faculty of Pharmacy, Utrecht University, The Netherlands.

Pharmacy World & Science : PWS
|August 20, 1993
PubMed
Summary

Vitamin E showed symptom improvement in tardive dyskinesia patients. However, large trials found no benefit for Parkinson's disease, suggesting it may not be an effective treatment for this neurodegenerative disorder.

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Area of Science:

  • Neurology
  • Nutritional Neuroscience

Background:

  • Extrapyramidal disorders, including tardive dyskinesia and Parkinson's disease, present complex neurological challenges.
  • Understanding the pathogenesis of these conditions is crucial for developing effective treatments.

Purpose of the Study:

  • To review the scientific literature on the efficacy of vitamin E in managing tardive dyskinesia and Parkinson's disease.
  • To synthesize findings from clinical trials investigating vitamin E's therapeutic potential.

Main Methods:

  • Review of existing clinical research, including double-blind, placebo-controlled trials.
  • Analysis of studies examining vitamin E's effects on symptom presentation and disease progression.

Main Results:

  • Four double-blind, placebo-controlled trials indicated symptom improvement in tardive dyskinesia with vitamin E (up to 1,600 IU/day).
  • Preliminary Parkinson's disease research suggested vitamin E (2,000 IU/day) might not prevent disease onset but could potentially slow progression.
  • A large double-blind, placebo-controlled trial found no beneficial effect of vitamin E in Parkinson's disease.

Conclusions:

  • Vitamin E demonstrates potential therapeutic benefits for tardive dyskinesia symptoms.
  • Current evidence does not support the use of vitamin E for Parkinson's disease treatment or prevention.

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