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Brain angiotensin AT-2 receptor antagonism and water intake
1Department of Psychology, University of Florida, Gainesville 32611-2065.
Brain Research Bulletin
|January 1, 1993
Abstract:
Intracerebroventricular administration of the angiotensin AT-2 receptor antagonist, PD 123319, inhibited drinking induced in rats by hypertonic NaCl, carbachol, isoproterenol, hypovolemia, and water deprivation, but had no effect on food intake. In contrast, the AT-1 antagonist, losartan potassium, had no effect on these intakes. A model of thirst is presented that incorporates an AT-2 receptor in a final common pathway for drinking.