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Related Experiment Videos

Why don't we use vitamin E in dermatology?

K Pehr1, R R Forsey

  • 1Division of Dermatology, McGill University, Montreal, Que.

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
|November 1, 1993
PubMed
Summary

Vitamin E (tocopherols) shows limited evidence for treating various skin conditions. Despite widespread use, robust clinical trials are needed to confirm its dermatologic effectiveness.

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Area of Science:

  • Dermatology
  • Nutritional Science
  • Biochemistry

Background:

  • Vitamin E, or tocopherols, are widely used by patients for various health concerns.
  • The therapeutic applications of vitamin E in dermatology remain a subject of ongoing investigation.

Purpose of the Study:

  • To critically review the existing evidence on the efficacy of topical and systemic tocopherols for treating dermatologic conditions.
  • To assess the current understanding of vitamin E's role in skin health and disease.

Main Methods:

  • Comprehensive literature search of Index Medicus (1922-1966) and MEDLINE (1966-present) for studies on vitamin E and dermatology.
  • Inclusion of only well-designed controlled studies, with anecdotal reports cited for historical context and future research direction.

Main Results:

  • Weak or conflicting evidence supports vitamin E's use in conditions like yellow nail syndrome, epidermolysis bullosa, and wound healing.
  • No significant benefit was observed for vitamin E in atopic dermatitis, psoriasis, porphyrias, or UV-induced skin damage.

Conclusions:

  • Decades of research provide insufficient proof of vitamin E's effectiveness for many dermatologic conditions.
  • Further well-designed, controlled clinical trials are essential to elucidate the true therapeutic role of vitamin E in dermatology.

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