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Effects of alprazolam on cellular immune response to surgical stress in mice
M Freire-Garabal1, M J Núñez, J L Balboa
1Neuroimmunology University of Santiago (NIMUS), Hospital de Conxo, Santiago de Compostela, Spain.
Mice exposed to surgical stress induced by laparotomy and treated with chronic alprazolam (0.5-2 mg/kg) showed a dose-dependent reduction in stress-induced suppression of the natural killer (NK) cell activity. These immunoenhancing effects of alprazolam were more intense when it administered before the surgery was performed.
Mice exposed to surgical stress induced by laparotomy and treated with chronic alprazolam (0.5-2 mg/kg) showed a dose-dependent reduction in stress-induced suppression of the natural killer (NK) cell activity. These immunoenhancing effects of alprazolam were more intense when it administered before the surgery was performed.