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Systematic HRAS amplification in ovary-independent mammary tumors: correlation with progressively anaplastic
C M Aldaz1, L S Gollahon, A Chen
1University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville 78957.
Cancer Research
|November 15, 1993
Abstract:
Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS allele. Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; in four of the cases the amplified sequences did not reside at the native chromosome 1 locus but were localized in a novel marker chromosome. The model described has potential as a reproducible system for the study of the chromosomal and cellular mechanisms operative "in vivo" for oncogene amplification.