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Published on: May 4, 2017
[Changes in interleukin-1 released by pulmonary alveolar macrophage in patients with interstitial lung disease]
1Respiratory Disease Institute, China Medical University.
Abstract:
To evaluate the activity of PAM, levels of IL-1 released by PAM in patients with ILD (non smokers) were measured using lipopolysaccharide (LPS) stimulation and thymocyte proliferation method, healthy non-smokers as control group. The results showed that IL-1 released by PAM in patient groups both with and without LPS stimulation were significantly higher than that in control group, and also IL-1 released by PAM in healthy smokers was significantly higher than that in health non-smokers. It was indicated that IL-1 might play an important role in the process of ILD and chronic pulmonary inflammation.

