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Related Experiment Videos

Computers in pharmacokinetics. Choosing software for clinical decision making

D E Buffington1, V Lampasona, M H Chandler

  • 1University of South Florida, College of Medicine, Division of Clinical Pharmacology, Tampa.

Clinical Pharmacokinetics
|September 1, 1993
PubMed
Summary

Clinical pharmacokinetic software aids drug monitoring by analyzing serum drug concentrations. Reviewing these programs helps clinicians understand features for better decision-making.

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Area of Science:

  • Pharmacokinetics
  • Clinical Pharmacology
  • Health Informatics

Background:

  • Clinical decision-making relies on pharmacokinetic programs for drug concentration analysis.
  • These software tools interpret and report drug levels, aiding therapeutic drug monitoring.
  • Program features and medication support vary, necessitating careful evaluation.

Purpose of the Study:

  • To review commercially available clinical pharmacokinetic software in the United States.
  • To inform clinicians about the features of computer-based resources for drug monitoring.
  • To focus on system and support aspects of these pharmacokinetic programs.

Main Methods:

  • Review of a series of commercially available pharmacokinetic software programs.
  • Focus on system and support features, not a ranked comparison.

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  • Assessment of capabilities for analyzing serum/plasma drug concentration data.

    • Main Results:

    • Reviewed programs assist in analyzing drug concentrations for most monitored medications.
    • Software offers both Bayesian and non-Bayesian prediction methods.
    • Standard personal computers suffice; most programs provide technical and clinical support, though manual/training quality varies.

    Conclusions:

    • Pharmacokinetic software is valuable for clinical decision support in drug monitoring.
    • Understanding program features, including system and support, is crucial for selection.
    • Further in-depth analytical comparisons are planned for future publication.