[Nizatidine: a meta-analytical study]

The medline database was applied to search all randomized clinical trials published from 1986 to 1992 concerning the use of Nizatidine, a powerful H2-antagonist, versus other treatments, including placebo, in the treatment of duodenal ulcer disease. Therapeutic efficacy of nizatidine is comparable to that of other H2-antagonists; with the use of meta-analysis, no significant differences were demonstrated, both in acute and long-term treatment of duodenal ulcer between nizatidine and ranitidine, but untoward side effects were less frequent with nizatidine than with ranitidine.