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Simple sequence repeat length polymorphisms mapped to rat chromosome 11

Y Du1, E F Remmers, E A Goldmuntz

  • 1Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD.

Cytogenetics and Cell Genetics
|January 1, 1994
PubMed
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Researchers mapped four DNA loci, including somatostatin (SST) and cell surface protein (MOX2) genes, to rat chromosome 11. This establishes a genetic linkage map and suggests conserved gene order with mouse chromosomes.

Area of Science:

  • Genetics and Genomics
  • Comparative Genomics
  • Molecular Biology

Background:

  • Genetic mapping is crucial for understanding chromosome organization and disease association.
  • Rat chromosome 11 harbors genes relevant to various biological functions.
  • Previous genetic maps of rat chromosome 11 were incomplete.

Purpose of the Study:

  • To construct a genetic linkage map for rat chromosome 11.
  • To identify the order and genetic distances of specific DNA loci on rat chromosome 11.
  • To investigate conserved synteny between rat and mouse chromosomes.

Main Methods:

  • Utilized F2 intercross progeny from Fischer (F344/N) and Lewis (LEW/N) inbred rat strains.
  • Employed Polymerase Chain Reaction (PCR)-based simple sequence repeat (SSR) length polymorphism detection.

Related Experiment Videos

  • Analyzed a panel of 13 inbred rat strains for allele frequency and diversity.

    • Main Results:

    • Successfully mapped two genes (somatostatin [SST] and cell surface protein [MOX2]) and two anonymous DNA loci (D11N161, D11N18) to rat chromosome 11.
    • Established a linkage group spanning 21.5 centimorgans (cM) with the order: SST-D11N161-D11N18-MOX2.
    • Detected four to seven alleles per marker across 13 rat strains, indicating significant genetic variation.

    Conclusions:

    • The developed genetic map provides a framework for future studies on rat chromosome 11.
    • The findings suggest significant syntenic conservation between rat chromosome 11 and mouse chromosome 16.
    • This comparative mapping aids in understanding genome evolution and identifying conserved functional regions.