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Increased lipoprotein (a) as an independent risk factor for cardiovascular and cerebrovascular diseases

Y Y Zhuang1, J J Wang, P Xu

  • 1Department of Biochemistry, Nanjing Jinling Hospital, Medical Institute of Nanjing University.

Chinese Medical Journal
|August 1, 1993
PubMed

Insights

Serum lipoprotein(a) [Lp(a)] is an independent risk factor for myocardial infarction (MI) and stroke. Elevated Lp(a) levels were observed in patients with these conditions compared to healthy individuals.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Chemistry
  • Epidemiology

Background:

  • Serum lipoprotein(a) [Lp(a)] is a lipoprotein particle implicated in cardiovascular disease.
  • Reference values for Lp(a) are crucial for clinical interpretation.
  • Previous studies suggest a link between Lp(a) and cardiovascular events, but its independent risk factor status requires further elucidation.

Purpose of the Study:

  • To establish reference values for serum Lp(a) in a healthy population stratified by age and sex.
  • To compare Lp(a) levels in patients with myocardial infarction (MI), stroke, and primary hypertension against age-matched controls.
  • To investigate the association of Lp(a) with other lipid parameters and its role as an independent risk factor for cardiovascular events.

Main Methods:

  • Serum Lp(a) was quantified in 1266 healthy individuals to establish reference ranges.
  • Lp(a) levels were measured in patients with MI, stroke, and primary hypertension and compared to controls.
  • Cholesterol, triglyceride, HDL-cholesterol, apo A1, and apo B were also measured in all participants.

Main Results:

  • Reference values for Lp(a) were established across different age and sex groups.
  • Lp(a) concentrations did not show correlation with other measured lipids (cholesterol, triglyceride, HDL-cholesterol, apo A1, apo B) in both controls and patients.
  • Abnormal lipid detection rates were significantly higher when Lp(a) was included in the assessment for MI and stroke patients.

Conclusions:

  • Increased serum Lp(a) is an independent risk factor for myocardial infarction and stroke.
  • Routine assessment of Lp(a) alongside other lipids can improve the detection of lipid abnormalities in patients at risk for cardiovascular events.

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