Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microbicidal effects of ozone solution on methicillin-resistant Staphylococcus aureus

T Yamayoshi1, N Tatsumi

  • 1Department of Environmental Microbiology, Osaka Prefectural Institute of Public Health, Japan.

Drugs Under Experimental and Clinical Research
|January 1, 1993
PubMed
Summary

Ozone solutions effectively disinfect against methicillin-resistant Staphylococcus aureus (MRSA) by damaging bacterial cell walls. This rapid antimicrobial action shows promise for disinfecting medical equipment and preventing infections from resistant strains.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deficiency in WT1-targeting microRNA-125a leads to myeloid malignancies and urogenital abnormalities.

Oncogene·2015
Same author

In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity.

Leukemia·2013
Same author

Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine.

Blood cancer journal·2013
Same author

Inwardly rectifying potassium channel Kir4.1 is localized at the calyx endings of vestibular afferents.

Neuroscience·2012
Same author

CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients.

Leukemia·2012
Same author

Diagnosis of infections in newborns using a new particle-mediated immunoassay for serum C-reactive protein.

The Journal of automatic chemistry·2008

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biochemistry

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant challenge in chemotherapy due to its resistance to standard disinfectants.
  • The increasing prevalence of antibiotic-resistant bacteria necessitates novel disinfection strategies.

Purpose of the Study:

  • To evaluate the efficacy of ozone solutions as a disinfectant against MRSA.
  • To determine the mechanism and speed of ozone's microbicidal action on MRSA.

Main Methods:

  • Exposure of MRSA strains to varying concentrations of ozone solutions.
  • Microscopic examination of bacterial cell structures after ozone treatment.
  • Time-kill assays to determine the rate of bacterial inactivation.

Related Experiment Videos

Main Results:

  • Ozone rapidly oxidizes bacterial cell walls and cytoplasmic membranes.
  • Complete microbicidal effect against MRSA was observed within five seconds of treatment.
  • A 1.5-fold higher ozone concentration than that for methicillin-sensitive strains effectively killed resistant isolates.

Conclusions:

  • Ozone solutions demonstrate potent and rapid antimicrobial activity against MRSA.
  • Ozone disinfection offers a viable method for medical instruments and equipment to combat resistant bacterial strains.
  • Ozone treatment can potentially reduce healthcare-associated infections stemming from inadequate disinfection protocols.