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Protective action of L-carnitine and coenzyme Q10 against hepatic triglyceride infiltration induced by hyperbaric
A Bertelli1, A Cerrati, L Giovannini
1Department of Medical Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Abstract:
This investigation was conducted to ascertain whether administration of L-carnitine and coenzyme Q10 could protect from the experimentally-induced hepatic lipid infiltration and glutathione content decrease in rats exposed to hyperbaric oxygen and prolonged alcohol administration. The results indicate that administration of L-carnitine and coenzyme Q10 in association reduces damage induced by chronic alcohol poisoning and hyperbaric oxygen. This protective action is more marked when L-carnitine and coenzyme Q10 are administered together. The combined complementary biochemical activity of these two compounds is discussed.