[Clinical study on the relationship between erythrocyte ATPase activity and lipid peroxidation in essential...

The changes of erythrocyte ATPase and superoxide dismutase (SOD) activity, intraerythrocytic ionic concentration and plasma lipid peroxide (LPO) were observed in 59 patients with essential hypertension (EH). The results showed that the Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase activity and SOD were significantly lower, Ca2+ and Na+ concentration and plasma LPO were significantly higher in EH than in normals. A significant linear relationship was found between the decline of ATPase activity and changes of LPO and SOD. Both LPO and Ca(2+)-concentration were positively correlated with mean arterial blood pressure. These findings suggest that lipid peroxidation, through inhibiting ATPase activity and increasing intracellular Ca2+ concentration, plays an important role in the pathogenesis of EH.