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Hypomelanosis of Ito and precocious puberty
P E Daubeney1, K Pal, R Stanhope
1Hospitals for Sick Children, London, United Kingdom.
European Journal of Pediatrics
|September 1, 1993
Abstract:
We describe two girls with hypomelanosis of Ito, one of whom was demonstrated to have diploid-triploid mixoploidy in skin fibroblasts. Both had precocious puberty which was probably gonadotrophin-independent. The association of precocious puberty and hypomelanosis of Ito has not been previously reported. We have speculated on the possible mechanism of gonadotrophin-independent precocious puberty.