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Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes
1Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
European Journal of Pharmacology
|August 3, 1993
Abstract:
The effects of arenobufagin, a bufadienolide isolated from toad venom, on the Na+/K+ pump were investigated by recording the whole-cell current of dissociated cardiac myocytes. Arenobufagin blocked the Na+/K+ pump current in a dose-dependent manner with a half-maximal concentration of 0.29 microM and a Hill coefficient of 1.1. Arenobufagin is 3.5-fold more potent than ouabain.