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Protective effect of SV-IV on platelet-activating factor-induced hypotension, bronchoconstriction and gastric mucosal
P Persico1, S Metafora, F Mancuso
1Department of Experimental Pharmacology, University of Naples Federico II, Italy.
European Journal of Pharmacology
|September 7, 1993
Abstract:
The inhibitory effect of one of the major proteins secreted by the rat seminal vesicles (SV-IV) on platelet-activating factor (PAF)-induced biological activities was investigated in vivo. SV-IV was found to prevent dose dependently both hypotension and acute bronchospasm caused by PAF administration in guinea-pigs. In addition, SV-IV inhibited both PAF- and ethanol-induced gastric mucosal injury in a dose-dependent manner.