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Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
Published on: August 10, 2012
Ultrastructural changes in rat mammotropes following incubation with dopamine
M Joneja1, C W Reifel, M L Murphy
1Department of Anatomy, Queen's University, Kingston, Ontario, Canada.
Experientia
|October 15, 1993
Abstract:
Cultured mammotropes incubated with dopamine for one hour exhibited changes in ultrastructure indicative of actively depressed biosynthetic and secretory activity. Peripheral relocation of rough endoplasmic reticulum appeared to create a barrier to secretory granule release by exocytosis. A decrease in the numbers of secretory granules indicated a decrease in prolactin production and enhanced lysosomal activity.
