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Attraction of human monocytes by the neuropeptide secretoneurin
N Reinisch1, R Kirchmair, C M Kähler
1Department of Internal Medicine, University of Innsbruck, Austria.
FEBS Letters
|November 8, 1993
Abstract:
Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.