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The Fenton reagents

S Goldstein1, D Meyerstein, G Czapski

  • 1Department of Physical Chemistry, Hebrew University of Jerusalem, Israel.

Free Radical Biology & Medicine
|October 1, 1993
PubMed
Summary

Fenton-like reagents, using transition metal complexes and hydrogen peroxide (H2O2), likely form transient complexes rather than outer-sphere electron transfer. The generation of hydroxyl radicals depends on the decomposition rates of these complexes.

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Area of Science:

  • Environmental Chemistry
  • Inorganic Chemistry
  • Physical Chemistry

Background:

  • Fenton reagents, traditionally iron and H2O2, generate hydroxyl radicals for oxidation.
  • Numerous transition metal ions and complexes exhibit similar oxidative properties, termed "Fenton-like" reagents.

Purpose of the Study:

  • To elucidate the reaction mechanism of Fenton-like reagents with H2O2.
  • To determine if hydroxyl radicals are always generated in these reactions.

Main Methods:

  • Application of Marcus theory to analyze reaction kinetics.
  • Review and synthesis of existing experimental data from literature.

Main Results:

  • The reaction between metal complexes and H2O2 typically does not proceed via outer-sphere electron transfer.
  • A transient metal-peroxide complex (LmM-H2O2n+) is likely formed as the initial step.
  • This complex can decompose to hydroxyl radicals or higher oxidation states of the metal, or react with organic substrates.

Conclusions:

  • Hydroxyl radical formation in Fenton-like reactions is not guaranteed and depends on competing reaction pathways.
  • The observed discrepancies in literature findings are attributed to varying relative rates of complex decomposition and substrate reaction.

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