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Primary sclerosing cholangitis and Hodgkin's disease
K M Man1, A Drejet, E B Keeffe
1Department of Transplantation, California Pacific Medical Center, San Francisco 94115.
Hepatology (Baltimore, Md.)
|November 1, 1993
Summary
Primary sclerosing cholangitis (PSC) and Hodgkin's disease (HD) may co-occur, presenting a newly identified association. Symptoms of HD can be obscured by advanced PSC, complicating diagnosis and treatment.
Area of Science:
- Hepatology
- Oncology
- Gastroenterology
Background:
- Primary sclerosing cholangitis (PSC) is a chronic liver disease.
- Hodgkin's disease (HD) is a cancer of the lymphatic system.
- The association between PSC and HD is not well-established.
Observation:
- Three male patients with PSC and HD were identified.
- One patient also had Crohn's disease.
- PSC preceded HD diagnosis by 2, 11, and 17 years.
Findings:
- All patients had advanced biliary cirrhosis requiring liver transplant evaluation.
- HD symptoms were often masked by PSC manifestations, especially biliary sepsis.
- HD can occur in PSC patients, particularly with advanced liver disease.
Implications:
- This highlights a previously unrecognized association between PSC and HD.
- The overlapping symptoms may delay HD diagnosis in PSC patients.
- Awareness is crucial for early detection and management of HD in PSC patients.