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Cephadroxil promotes vaginal colonization with Escherichia coli
J Winberg1, L Gezelius, L Guldevall
1Dept. of Pediatrics, Karolinska Hospital, Stockholm, Sweden.
Infection
|July 1, 1993
Summary
Local cephadroxil administration can induce persistent vaginal Escherichia coli colonization in non-human primates, potentially increasing urinary tract infection (UTI) risk in susceptible individuals.
Area of Science:
- Microbiology
- Pharmacology
- Urology
Background:
- Recurrent urinary tract infections (UTIs) are common in susceptible individuals.
- Understanding the mechanisms of bacterial colonization is crucial for preventing UTIs.
Purpose of the Study:
- To investigate if local cephadroxil administration can induce vaginal Escherichia coli colonization.
- To assess the impact of cephadroxil on E. coli colonization resistance.
Main Methods:
- Adult cynomolgus monkeys were used as a model.
- Vaginal colonization attempts with a P-fimbriated E. coli strain were performed.
- Cephadroxil administration preceded some colonization attempts.
Main Results:
- Vaginal flushing with E. coli alone did not result in persistent colonization.
- Preceding cephadroxil administration led to persistent E. coli colonization in 9/10 experiments.
- Cephadroxil promoted the spread of fecal E. coli strains to the vagina, likely by reducing anaerobic vaginal flora.
Conclusions:
- Cephadroxil disrupts vaginal colonization resistance, facilitating E. coli persistence.
- Antibiotics like cephadroxil that promote E. coli vaginal colonization may increase UTI risk in susceptible patients.
- Cephadroxil might be less suitable for treating UTI-prone individuals.