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In vitro interaction between clindamycin and trimethoprim in combination on staphylococci
W el-Baz1, T Abd-el Hamid, A Tantawi
1Department of Medicine, Ain-Shams University, Cairo, Egypt.
International Journal of Clinical Pharmacology Research
|January 1, 1993
Summary
The combination of clindamycin and trimethoprim showed indifference or antagonism against Staphylococcus strains. This antibiotic combination is not recommended for synergistic anti-staphylococcal effects but may benefit certain polymicrobial infections.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Staphylococcus species are significant human pathogens.
- Antibiotic combinations are explored to enhance efficacy and combat resistance.
- Clindamycin and trimethoprim are commonly used antibiotics with distinct mechanisms of action.
Purpose of the Study:
- To investigate the in vitro synergistic, indifferent, or antagonistic interactions between clindamycin and trimethoprim against clinical isolates of Staphylococcus.
- To evaluate the potential clinical utility of this antibiotic combination.
Main Methods:
- Checkerboard technique was employed to assess drug interactions.
- Time-kill curve analysis was performed to determine bactericidal or bacteriostatic effects.
- Ten clinical isolates of Staphylococcus were used in the study.
Main Results:
- The clindamycin/trimethoprim combination demonstrated indifference against seven Staphylococcus strains.
- Antagonistic effects were observed against three Staphylococcus strains.
- The combination showed no synergistic activity against the tested staphylococcal isolates.
Conclusions:
- Clindamycin and trimethoprim combination lacks synergy against Staphylococcus.
- This combination may be beneficial for treating mild polymicrobial infections involving Gram-positive aerobes, anaerobes, and Enterobacteriaceae.
- Further research is warranted to define the precise role of this combination in polymicrobial infections.