Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute effects of cocaine on cochlear function

B G Shivapuja1, Z P Gu, S S Saunders

  • 1Department of Otolaryngology, Henry Ford Hospital, Detroit, MI 48202.

Hearing Research
|September 1, 1993
PubMed
Summary

Cocaine negatively impacts hearing by reducing auditory nerve responses in a dose-dependent manner. This study links these auditory changes to decreased cochlear blood flow following cocaine administration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Nonsyndromic deafness and mitochondrial DNA mutation].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology·2003
Same author

[Genetic epidemiologic study of mitochondrial DNA 7445A-->G mutation among non-syndromic deafness in Chinese population].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology·2003
Same author

Apoptosis induced by droloxifene and C-myc, Bax, Bcl-2 protein expression in corpus luteum of pregnant rats.

Acta pharmacologica Sinica·2001
Same author

Effects of droloxifene on apoptosis and Bax, Bcl-2 protein expression of luteal cells in pseudopregnant rats.

Acta pharmacologica Sinica·2001
Same author

Inhibitory effect of nomegestrol acetate on steroidogenesis of cultured granulosa cells from rat ovary in vitro.

Acta pharmacologica Sinica·2001
Same author

[Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice].

Yao xue xue bao = Acta pharmaceutica Sinica·2001

Area of Science:

  • Neuroscience
  • Ototoxicology
  • Pharmacology

Background:

  • Cocaine use can lead to various adverse health effects.
  • The specific impact of cocaine on the auditory system, particularly the cochlea, is not fully understood.

Purpose of the Study:

  • To investigate the effects of acute cocaine administration on cochlear function.
  • To determine if cocaine-induced changes in cochlear blood flow (CBF) correlate with auditory nerve response alterations.

Main Methods:

  • Auditory nerve N1 response amplitude-intensity functions were measured in response to various tone frequencies.
  • Measurements were taken before and after intraperitoneal injection of saline, 3 mg/kg, or 25 mg/kg cocaine.
  • Cochlear blood flow was assessed following cocaine exposure.

Main Results:

  • Cocaine administration led to a dose-dependent decrease in N1 response amplitudes.
  • A reduction in cochlear blood flow was observed after cocaine exposure.
  • The observed electrophysiological changes in the auditory nerve correlate with decreased CBF.

Conclusions:

  • Cocaine exposure adversely affects cochlear function.
  • Reduced cochlear blood flow is a likely mechanism underlying cocaine-induced auditory nerve dysfunction.
  • These findings highlight a potential ototoxic effect of cocaine.

Related Experiment Videos