Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Immune regulation: learning from leprosy

R L Modlin¹, B R Bloom

¹Division of Dermatology, University of California, Los Angeles, School of Medicine.

Hospital Practice (Office Ed.)

|November 15, 1993

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Monoclonal antibodies against mycobacterial antigens.

Immunology today·2014

Same author

Mutually dependent secretion of proteins required for mycobacterial virulence.

Proceedings of the National Academy of Sciences of the United States of America·2005

Same author

Chips, infections, and national security.

Science (New York, N.Y.)·2001

Same author

Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns.

Journal of immunology (Baltimore, Md. : 1950)·2001

Same author

Immunology. Chip shots--will functional genomics get functional?

Science (New York, N.Y.)·2001

Same author

Activation of toll-like receptors by microbial lipoproteins: role in host defense.

The Journal of allergy and clinical immunology·2001

Same journal

Oral contraceptives: an update.

Hospital practice (Office ed.)·1995

Same journal

Progress in the immunogenetics of rheumatoid arthritis.

Hospital practice (Office ed.)·1995

Same journal

An asymptomatic lung nodule in an elderly woman with joint pain.

Hospital practice (Office ed.)·1995

Same journal

Defusing status epilepticus.

Hospital practice (Office ed.)·1995

Same journal

Persistent fever and flank discomfort in a young woman.

Hospital practice (Office ed.)·1995

Same journal

New thoughts on attention-deficit/hyperactivity disorder.

Hospital practice (Office ed.)·1995

See all related articles

Severe leprosy involves complex immune cell actions, particularly macrophages and T lymphocytes. Cytokine mediation explains immune defense choices and suggests immunotherapy targets for infectious and autoimmune diseases.

Area of Science:

Immunology
Cellular Biology
Infectious Disease Research

Background:

Leprosy, particularly severe disseminated forms, is characterized by specific immune anergy.
This anergy involves complex interactions between macrophages and suppressor T lymphocytes.
Understanding these interactions is crucial for developing effective treatments.

Purpose of the Study:

To elucidate the mechanisms underlying immune anergy in severe leprosy.
To identify the role of cytokine mediation in directing immune responses.
To explore potential cytokine-based immunotherapeutic strategies for infectious and autoimmune diseases.

Main Methods:

Analysis of macrophage and T lymphocyte functions in leprosy patients.
Investigation of cytokine profiles associated with disease severity.

Related Experiment Videos

Correlation of immune cell activity with specific cytokine mediators.

Main Results:

Multifaceted actions of macrophages and suppressor T lymphocytes contribute to immune anergy in leprosy.
Cytokine mediation plays a key role in the immune system's preference for cellular over humoral defenses.
Specific cytokine pathways were identified in severe, disseminated leprosy.

Conclusions:

The immune anergy in leprosy is a result of complex cellular interactions modulated by cytokines.
Cytokine "switches" can be manipulated for novel immunotherapies.
This research opens avenues for treating infectious and autoimmune conditions by targeting cytokine pathways.