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Related Experiment Videos

Hypochromic macrocytes: are they reticulocytes?

B J Bain1, I A Cavill

  • 1Department of Haematology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London.

Journal of Clinical Pathology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

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Automated blood cell counters can identify abnormal red blood cells. An increase in hypochromic macrocytes often signals a higher reticulocyte count, alerting hematologists to potential issues.

Area of Science:

  • Hematology
  • Clinical Pathology
  • Red Blood Cell Morphology

Background:

  • Automated hematology analyzers utilize light scatter to assess red blood cell (RBC) characteristics.
  • RBC indices, including size and hemoglobin concentration, can indicate cellular abnormalities.
  • Hypochromic macrocytes, large RBCs with low hemoglobin, are a specific morphological finding.

Purpose of the Study:

  • To investigate the relationship between hypochromic macrocytes and reticulocytosis.
  • To determine if hypochromic macrocyte percentage can predict reticulocyte counts.

Main Methods:

  • Utilized automated full blood counters with high and low angle light scatter technology.
  • Measured the percentage of hypochromic macrocytes in blood samples.

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  • Correlated these percentages with concurrently measured reticulocyte counts.

    • Main Results:

    • A statistically significant correlation was observed between the percentage of hypochromic macrocytes and the reticulocyte count.
    • The correlation was insufficient to accurately predict specific reticulocyte percentages.
    • Elevated hypochromic macrocyte percentages frequently corresponded with increased reticulocyte counts.

    Conclusions:

    • Increased hypochromic macrocytes are a potential indicator of reticulocytosis.
    • This finding can serve as a valuable alert for hematologists to investigate further.
    • Automated analysis of RBC morphology provides useful, though not definitive, diagnostic clues.