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Intralymphatic Immunotherapy and Vaccination in Mice
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Published on: February 2, 2014

Active specific immunotherapy of malignant melanoma with anti-idiotypic monoclonal antibodies

S Ferrone1, T Kageshita, S Hirai

  • 1Department of Microbiology and Immunology, New York Medical College, Valhalla 10595.

The Journal of Dermatology
|September 1, 1993
PubMed

In this study, we have utilized the human high molecular weight-melanoma associated antigen (HMW-MAA) as a target for active specific immunotherapy with mouse anti-idiotypic (anti-id) monoclonal antibodies (mAb) in patients with malignant melanoma. After having summarized the characteristics of HMW-MAA which account for its selection as a target for immunotherapy, we describe the development and characterization of mouse anti-id mAb MK2-23 which bears the internal image of HMW-MAA. Furthermore, we describe the results of the first clinical trial performed with mouse anti-id mAb MK2-23 in patients with malignant melanoma.

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