Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perspectives for the future

E F Mammen1

  • 1Department of Pathology, Wayne State University School of Medicine, Detroit, MI.

Intensive Care Medicine
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Sepsis pathophysiology involves complex mediator release, causing "metabolic anarchy." Novel therapies target inhibitors and antibodies to manage disseminated intravascular coagulation (DIC) and complement activation, requiring a multifaceted approach.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disseminated intravascular coagulation (DIC).

Clinical laboratory science : journal of the American Society for Medical Technology·2001
Same author

Oral contraceptive pills and hormonal replacement therapy and thromboembolic disease.

Hematology/oncology clinics of North America·2000
Same author

Low molecular weight heparins and heparin-induced thrombocytopenia.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2000
Same author

The effects of a low-dose monophasic preparation of levonorgestrel and ethinyl estradiol on coagulation and other hemostatic factors.

American journal of obstetrics and gynecology·1999
Same author

Sticky platelet syndrome.

Seminars in thrombosis and hemostasis·1999
Same author

Clinical differentiation of low molecular weight heparins.

Seminars in thrombosis and hemostasis·1999
Same journal

Publisher Correction: Current knowledge and challenges of sepsis-associated encephalopathy.

Intensive care medicine·2026
Same journal

Prehospital airway and ventilatory management: a collaborative and narrative review.

Intensive care medicine·2026
Same journal

Rapid coma with bilateral basal ganglia involvement.

Intensive care medicine·2026
Same journal

From size to function: moving beyond body mass index to frailty and central adiposity phenotypes.

Intensive care medicine·2026
Same journal

Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial.

Intensive care medicine·2026
Same journal

Hypercalcemia in intensive care unit: pathophysiological mechanisms and clinical implications.

Intensive care medicine·2026
See all related articles

Area of Science:

  • Critical Care Medicine
  • Immunology
  • Pathophysiology

Background:

  • Sepsis pathophysiology is complex, involving widespread physiological disruption initiated by endotoxins.
  • Mediator release leads to dysregulation, termed "metabolic anarchy," affecting multiple systems.
  • Key systems involved include coagulation (leading to DIC) and the complement system.

Purpose of the Study:

  • To review the complex pathophysiology of sepsis and septic shock.
  • To discuss current and emerging therapeutic strategies targeting key pathways.

Main Methods:

  • Review of existing literature on sepsis pathophysiology and treatment.
  • Analysis of the role of mediators, cytokines, and system activations.

Main Results:

Related Experiment Videos

  • Endotoxin triggers mediator release, causing systemic dysregulation and "metabolic anarchy."
  • Tumor necrosis factor alpha and other cytokines activate coagulation (DIC) and complement systems.
  • Emerging treatments include inhibitors of coagulation and complement, and antibodies against TNF-alpha and endotoxin.

Conclusions:

  • Sepsis and septic shock necessitate a comprehensive, multifaceted therapeutic strategy.
  • Targeting specific pathways like coagulation and complement activation shows promise.
  • Future treatments may involve immunomodulatory agents and endotoxin neutralization.