Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coagulation disorders in septic shock

L G Thijs1, J P de Boer, M C de Groot

  • 1Medical Intensive Care Unit, Free University Hospital, Amsterdam, The Netherlands.

Intensive Care Medicine
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment-related hearing loss in weekly versus triweekly cisplatin chemoradiation for head and neck cancer.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2024
Same author

Muscarinic inhibition of salivary glands with glycopyrronium bromide does not reduce the uptake of PSMA-ligands or radioiodine.

EJNMMI research·2021
Same author

[Papillary carcinoma in a thyroglossal duct cyst; diagnostics and treatment].

Nederlands tijdschrift voor geneeskunde·2020
Same author

Laryngo-esophageal dysfunction free survival and propensity score matched analysis comparing organ preservation and total laryngectomy in hypopharynx cancer.

Oral oncology·2019
Same author

Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; an exploratory study.

PloS one·2019
Same author

From reactive to proactive tube feeding during chemoradiotherapy for head and neck cancer: A clinical prediction model-based approach.

Oral oncology·2019
Same journal

Publisher Correction: Current knowledge and challenges of sepsis-associated encephalopathy.

Intensive care medicine·2026
Same journal

Prehospital airway and ventilatory management: a collaborative and narrative review.

Intensive care medicine·2026
Same journal

Rapid coma with bilateral basal ganglia involvement.

Intensive care medicine·2026
Same journal

From size to function: moving beyond body mass index to frailty and central adiposity phenotypes.

Intensive care medicine·2026
Same journal

Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial.

Intensive care medicine·2026
Same journal

Hypercalcemia in intensive care unit: pathophysiological mechanisms and clinical implications.

Intensive care medicine·2026
See all related articles

Septic shock disrupts blood clotting and clot breakdown, leading to disseminated intravascular coagulation. These coagulation and fibrinolysis abnormalities predict organ failure and death in patients.

Area of Science:

  • Hematology
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Septic shock frequently involves coagulation and fibrinolysis abnormalities.
  • Disseminated intravascular coagulation is a key clinical manifestation.
  • Early dynamics of coagulation and fibrinolysis are increasingly understood.

Purpose of the Study:

  • To investigate the dynamics of coagulation and fibrinolysis in septic shock.
  • To clarify the prognostic significance of these abnormalities.

Main Methods:

  • Review of recent studies in human volunteers and animal models.
  • Analysis of coagulation and fibrinolysis pathways in healthy subjects and septic shock patients.

Main Results:

Related Experiment Videos

  • Healthy subjects show a procoagulant state upon endotoxin or TNF exposure.
  • Septic shock patients exhibit ongoing dynamic changes in coagulation and fibrinolysis.
  • Impaired fibrinolysis is evident in septic shock patients.
  • The severity of these disturbances correlates with organ failure and mortality.

    • Conclusions:

    • Coagulation and fibrinolysis abnormalities are central to septic shock pathophysiology.
    • Impaired fibrinolysis and coagulation disturbances are significant prognostic indicators for septic shock outcomes.
    • Understanding these dynamics is crucial for predicting patient prognosis and guiding treatment.