Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular function immediately after intravenous cocaine: a quantitative two-dimensional echocardiographic

M J Eisenberg1, J Mendelson, G T Evans

  • 1Cardiovascular Research Institute, University of California, San Francisco 94143.

Journal of the American College of Cardiology
|November 15, 1993
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial Expression of Concern: Disruption of transforming growth factor-β signaling through β-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation.

Oncogene·2026
Same author

[Off-label psychopharmacological prescription in thirteen forensic outpatient clinics].

Tijdschrift voor psychiatrie·2025
Same author

Protective factors as uni- or bipolar factors and their incremental validity and accuracy in predicting general recidivism.

International journal of law and psychiatry·2021
Same author

Saddle-back tamarin (Saguinus fuscicollis) reproductive strategies: Evidence from a thirteen-year study of a marked population.

American journal of primatology·2020
Same author

Non-medical cannabis in North America: an overview of regulatory approaches.

Public health·2019
Same author

Prevalence and outcomes of prenatal recreational cannabis use in high-income countries: a scoping review.

BJOG : an international journal of obstetrics and gynaecology·2019

Intravenous cocaine, at common recreational doses, did not cause acute myocardial ischemia or left ventricular dysfunction in study participants. Researchers suggest other mechanisms for cocaine-induced cardiac events, such as vasospasm or thrombosis.

Area of Science:

  • Cardiology
  • Pharmacology
  • Toxicology

Background:

  • Cocaine use is a growing cause of cardiac complications and death in young individuals.
  • The precise mechanisms underlying cocaine-induced cardiac damage remain unclear.

Purpose of the Study:

  • To investigate whether intravenous cocaine, at typical self-administered doses, induces acute myocardial ischemia and left ventricular dysfunction.
  • To clarify the cardiac effects of recreational cocaine use.

Main Methods:

  • A double-blind, placebo-controlled study involving 20 subjects.
  • Administration of single intravenous doses of high-dose (1.2 mg/kg) and low-dose (0.6 mg/kg) cocaine, or placebo.
  • Utilized 12-lead electrocardiography and quantitative two-dimensional echocardiography for cardiac assessment.

Related Experiment Videos

Main Results:

  • Cocaine significantly increased heart rate and blood pressure (rate-pressure product) compared to placebo.
  • Electrocardiography showed dose-related nonspecific changes in some subjects after cocaine administration.
  • Echocardiography revealed increased hyperdynamic left ventricular segments but no significant changes in ejection fraction or wall motion score index.

Conclusions:

  • Intravenous cocaine, at commonly self-administered doses, does not appear to cause acute myocardial ischemia or left ventricular dysfunction.
  • Cocaine-induced cardiac complications may result from idiosyncratic coronary artery vasospasm, extremely high dosages, or cocaine-induced coronary artery thrombosis.