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Collodion baby: the out-come of long-term follow-up
1Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Insights
This study followed 10 Thai collodion babies, finding lamellar ichthyosis in 50%. Many infants were premature and experienced developmental delays, highlighting the severe impact of this rare skin condition.
Area of Science:
- Pediatrics
- Dermatology
- Genetics
Background:
- Collodion babies represent a rare neonatal presentation of severe ichthyosis.
- Early diagnosis and management are crucial for improving outcomes.
- Understanding the long-term sequelae is essential for comprehensive care.
Purpose of the Study:
- To describe the clinical characteristics and outcomes of Thai collodion babies.
- To identify associated conditions and long-term developmental trajectories.
- To contribute to the understanding of ichthyosis subtypes in a specific population.
Main Methods:
- Retrospective case series analysis of 10 Thai infants presenting as collodion babies.
- Review of clinical records, histopathology, and follow-up data from 1970-1990.
- Assessment of infant demographics, family history, disease severity, and developmental milestones.
Main Results:
- 50% of cases were diagnosed with lamellar ichthyosis, often associated with mental retardation and developmental delay.
- Prematurity and small for gestational age were common.
- Other outcomes included ichthyosis vulgaris, palmoplantar hyperkeratosis, respiratory infection, and congenital anomalies.
Conclusions:
- Lamellar ichthyosis is a significant outcome in Thai collodion babies, frequently linked to intellectual and developmental disabilities.
- Collodion baby presentation warrants thorough investigation for underlying ichthyosis subtypes and associated complications.
- Long-term follow-up is critical for managing the multifaceted challenges faced by affected individuals.
Abstract:
About 10 Thai collodion babies were treated at the Department of Pediatrics, Faculty of Medicine, Chulalongkorn University from 1970 to 1990. Most of them were premature and small for gestational age infants. The sex incidence of males to female was 3:2. Only half of the cases had a family history of ichthyosis. The severity of thickness and tightness of the collodion membranes varied from mild to severe. The clinical and histopathologic findings revealed 5 cases of lamellar ichthyosis (50%), of which one case had episodes of pustular psoriasis. One case evolved to be ichthyosis vulgaris 10 per cent, one case had palmoplantar hyperkeratosis (10%), one case had been apparently normal up to 18 years old, one died of respiratory infection and another case was lost from follow-up. All cases of lamellar ichthyosis were associated with mental retardation with some degree of slow physical development. One severe collodion baby suffered from congenital absence of distal phalanges of toes with increased thickness of the finger nails.