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Blood lipids, the risk factor of cerebral infarction
1Prasat Neurological Hospital and Institute, Bangkok, Thailand.
Insights
High total cholesterol is linked to cerebral infarction (stroke). While triglycerides were not significant, hypertension, cardiac issues, and diabetes are also major stroke risk factors. Interaction between triglycerides and diabetes was noted.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Epidemiology
Background:
- Cerebral infarction (stroke) is a significant health concern.
- Understanding the association between blood lipid profiles and stroke is crucial for prevention and treatment.
Purpose of the Study:
- To investigate the relationship between blood lipid variables (total cholesterol and triglycerides) and cerebral infarction.
- To identify other risk factors associated with cerebral infarction.
Main Methods:
- A hospital-based case-control study was conducted with 193 cerebral infarction patients and 193 matched controls.
- Logistic regression analysis was used to assess associations, adjusting for covariates like hypertension, cardiac impairment, and diabetes mellitus.
Main Results:
- Total cholesterol and triglycerides showed a significant association with cerebral infarction in univariate analysis.
- After multivariate adjustment, total cholesterol remained a significant risk factor (p=0.0430), but triglycerides did not (p=0.3953).
- Hypertension, cardiac impairment, diabetes mellitus, and hemoglobin concentration were strongly associated with cerebral infarction.
Conclusions:
- Elevated total cholesterol is a significant risk factor for cerebral infarction.
- A significant multiplicative interaction was observed between triglyceride levels and diabetes mellitus status.
- Comprehensive risk factor management, including blood pressure and diabetes control, is vital for stroke prevention.
Abstract:
A hospital-based case-control study was undertaken at Prasat Neurological Hospital and Institute, Bangkok, in 1990 to determine the association between blood lipid variables (i.e., total cholesterol and triglycerides) and cerebral infarction. To alleviate the unwanted effects of sample selection a number of inclusion and exclusion criteria were also made. A total of 193 newly diagnosed cerebral infarction patients together with an equal number of age-sex-matched controls, male and female 45 to 84 years of age, were studied. The association was assessed by logistic regression analysis. Other potential risk factors for cerebral infarction were entered in the logistic models as covariates to be adjusted. The results showed that, total cholesterol and triglycerides were statistically significant related to cerebral infarction (p < 0.0001) in univariated analysis. After adjusting for the covariates through multivariate logistic regression analyses, total cholesterol remained significantly related to cerebral infarction (p = 0.0430) but triglycerides was not significant (p = 0.3953). Other factors, namely, hypertension, cardiac impairment, diabetes mellitus and hemoglobin concentration were strongly related to cerebral infarction in both the univariate and multivariate analyses. The interaction between blood lipids variables and potential risk factors was also assessed. The finding showed significant multiplicative interaction between triglyceride levels and diabetes mellitus status (p = 0.0026). Other interaction terms did not approach statistical significance.