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Avoidance behavior and ileum motility post-cingulumotomy in monkey

R G Haller, J S Lockard, E L Foltz

    Biological Psychiatry
    |April 1, 1976
    PubMed
    Summary
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    Cingulumotomy impaired passive avoidance learning in rhesus monkeys but not active avoidance. Ileum motility and avoidance behavior were found to be correlated, with cingulum-lesioned monkeys showing reduced reactivity.

    Area of Science:

    • Neuroscience
    • Animal Behavior
    • Gastrointestinal Physiology

    Background:

    • The cingulum bundle is a crucial white matter tract in the brain involved in various cognitive functions.
    • Understanding the neural underpinnings of avoidance learning and its physiological correlates is essential for behavioral neuroscience.
    • Previous research has explored lesion effects on behavior, but the impact on gastrointestinal motility remains less understood.

    Purpose of the Study:

    • To investigate the effects of cingulumotomy on the acquisition and extinction of conditioned-avoidance behaviors in rhesus monkeys.
    • To examine how avoidance learning influences distal ileum motility in both control and cingulum-lesioned animals.
    • To explore potential correlations between avoidance learning, behavioral reactivity, and gastrointestinal motility.

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    Main Methods:

    • Two experiments were conducted using rhesus monkeys.
    • Active (AAR) and passive (PAR) avoidance schedules were employed during training, acquisition, and extinction phases.
    • Distal ileum motility was monitored in control and cingulum-lesioned animals.

    Main Results:

    • Cingulumotomy did not affect active avoidance acquisition or extinction.
    • Cingulum-lesioned monkeys exhibited significant deficits in passive avoidance acquisition.
    • A slower lever-pulling rate was observed in cingulum group during combined avoidance training.
    • Ileum motility and avoidance behavior showed parallel changes; cingulum monkeys were less reactive and had more regular motility patterns.

    Conclusions:

    • Cingulumotomy selectively impairs passive avoidance learning in rhesus monkeys.
    • Avoidance behavior and distal ileum motility are interconnected, suggesting a potential neuro-visceral link.
    • Cingulum lesions may reduce overall behavioral reactivity and alter gastrointestinal motility patterns.