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Transferrin subtyping in dental pulps

A Kido1, Y Kimura, M Oya

  • 1Department of Legal Medicine, Yamanashi Medical University, Tamaho, Japan.

Journal of Forensic Sciences
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

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Serum transferrin (TF) subtypes found in dental pulps match serum types. This genetic marker is reliable for up to 4 weeks post-extraction, aiding in dental identification.

Area of Science:

  • Forensic Science
  • Genetics
  • Biochemistry

Background:

  • Serum transferrin (TF) is a protein involved in iron transport.
  • Genetic variations in TF exist and can be identified in biological samples.
  • Dental pulp is a potential source of genetic material for identification.

Purpose of the Study:

  • To investigate the presence and subtypes of transferrin in dental pulp.
  • To determine if dental pulp TF subtypes correlate with serum TF subtypes.
  • To assess the utility of TF subtypes as a genetic marker for dental individualization.

Main Methods:

  • Isoelectric focusing and immunoblotting techniques were used.
  • Dental pulp and serum samples from the same individuals were analyzed.
  • TF allele frequencies were calculated for TF*C1 and TF*C2.

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Main Results:

  • TF subtypes were successfully identified in dental pulps.
  • Dental pulp TF subtypes showed complete agreement with serum samples.
  • TF allele frequencies were TF*C1 = 0.757 and TF*C2 = 0.243.
  • Reliable subtyping was possible for up to 4 weeks after tooth extraction.

Conclusions:

  • Transferrin subtypes are present in dental pulp and reflect an individual's genetic profile.
  • The TF system serves as a valuable genetic marker for the medicolegal identification of teeth.
  • This method offers a reliable approach for forensic individualization using dental remains.