Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sympathetic skin response in multiple sclerosis

J A Gutrecht1, G A Suarez, B E Denny

  • 1Department of Neurology, Lahey Clinic, Burlington, MA 01805.

Journal of the Neurological Sciences
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of congenital midline nasofrontal masses: case report and review of literature.

Case reports in otolaryngology·2015
Same author

Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome.

American journal of physiology. Heart and circulatory physiology·2005
Same author

Sudden cardiac death in diabetes mellitus: risk factors in the Rochester diabetic neuropathy study.

Journal of neurology, neurosurgery, and psychiatry·2005
Same author

Diagnostic accuracy and certainty from sequential evaluations in peripheral neuropathy.

Neurology·2001
Same author

Basal forebrain malformation with hyperhidrosis and hypothermia: variant of Shapiro's syndrome.

Neurology·2001
Same author

International regulations for automobile driving and epilepsy.

Journal of travel medicine·2000
Same journal

Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

Journal of the neurological sciences·2026
Same journal

Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

Journal of the neurological sciences·2026
Same journal

Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

Journal of the neurological sciences·2026
Same journal

Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

Journal of the neurological sciences·2026
Same journal

Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

Journal of the neurological sciences·2026
Same journal

Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

Journal of the neurological sciences·2026
See all related articles

Multiple sclerosis (MS) patients often show abnormal sympathetic skin responses (SSRs), indicating nerve damage. Absent SSRs correlate with MS disability severity and specific neurological deficits, suggesting spinal cord fiber damage.

Area of Science:

  • Neurology
  • Autonomic Nervous System Function

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease affecting the central nervous system.
  • Autonomic dysfunction is a known complication of MS, impacting various bodily functions.

Purpose of the Study:

  • To investigate somatosympathetic reflex activity in patients with multiple sclerosis using the sympathetic skin response (SSR) method.
  • To correlate SSR abnormalities with MS disability severity and specific clinical symptoms.

Main Methods:

  • Non-invasive sympathetic skin response (SSR) measurements were performed on 29 patients with definite multiple sclerosis.
  • SSR abnormalities were assessed in multiple limbs and correlated with clinical data and MRI findings.

Main Results:

Related Experiment Videos

  • Abnormal SSRs were observed in 17 out of 29 patients.
  • A strong correlation was found between the number of absent SSRs and the severity of MS-related disability.
  • Delayed or absent SSRs were associated with leg weakness, spinothalamic sensory deficits, and neurogenic bladder.
  • No correlation was found between SSR abnormalities and MRI signal changes in the hypothalamus or brain stem.

Conclusions:

  • Absent or delayed SSRs in MS patients likely result from damage to central sympathetic fibers within the spinal cord.
  • The lateral columns of the spinal cord are suggested as the probable location of this sympathetic fiber damage.