[Lymphadenopathy in phenytoin treatment (author's transl)]

In a 15-year-old female patient treated with phenytoin (100 mg tds) for symptomatic epilepsy generalised enlargement of lymph nodes, particularly in the cervical region, occurred three weeks after beginning treatment. The histological findings suggested lymphogranulomatosis which could not be confirmed clinically. Despite continuation of phenytoin treatment the lymphoma regressed spontaneously. It appears to have been a rare case of an allergic reaction to phenytoin.